Humans

Overview of BioCreative II gene normalization.

BACKGROUND: The goal of the gene normalization task is to link genes or gene products mentioned in the literature to biological databases. This is a key step in an accurate search of the biological literature. It is a challenging task, even for the …

Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus.

BACKGROUND: Nicotine dependence (ND) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci can be identified with genetic linkage analysis independent of prior physiological hypotheses. METHODS: We completed a …

The BiolAD-DB system : an informatics system for clinical and genetic data.

The Biology of Addictive Diseases-Database (BiolAD-DB) system is a research bioinformatics system for archiving, analyzing, and processing of complex clinical and genetic data. The database schema employs design principles for handling complex …

Towards semantic role labeling & IE in the medical literature.

INTRODUCTION: In this work, we introduce the concept of semantic role labeling to the medical domain. We report first results of porting and adapting an existing resource, Propbank, to the medical field. Propbank is an adjunct to Penn Treebank that …

Term identification in the biomedical literature.

Sophisticated information technologies are needed for effective data acquisition and integration from a growing body of the biomedical literature. Successful term identification is key to getting access to the stored literature information, as it is …

Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease.

A major challenge in human genetics is identifying the molecular basis of common heritable disorders. In contrast to rare single-gene diseases, multifactorial disorders are thought to arise from the combined effect of multiple gene variants, such …