Home
Projects
Posts
Publications
Our Team
Job Opportunities
Contact
Mutant Proteins
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors.
BRAF inhibitors improve melanoma patient survival, but resistance invariably develops. Here we report the discovery of a novel BRAF mutation that confers resistance to PLX4032 employing whole-exome sequencing of drug-resistant BRAF(V600K) melanoma …
Cite
×