Cancer Research

COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma

We identified COL10A1 as a marker of high-risk BCC subtypes, particularly in sclerosing/infiltrative and basosquamous subtypes. This could serve as a prognostic biomarker and a target for personalized treatment.

ROS induction targets persister cancer cells with low metabolic activity in NRAS-mutated melanoma

This study explores a new therapeutic approach for NRAS-mutated melanomas, targeting drug-resistant cells through ROS induction and metabolic vulnerabilities.

Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for cancer pharmacogenetics

Investigating PDE4B variants in Native American populations, this study highlights their impact on ALL relapse and the need for personalized treatment approaches.